PREPARATION OF IMMEDIATE RELEASE TABLETS OF REPAGLINIDE BY A SOLUBILITY ENHANCER AND HOT-MELT EXTRUSION METHOD
نویسندگان
چکیده
منابع مشابه
Hot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملHot-melt extrusion of polyvinyl alcohol for oral immediate release applications.
The primary purpose of this study was to process partially hydrolyzed PVOH grades (degree of hydroxylation (DH): 33-88%) via HME and to evaluate them as carrier for oral immediate release dosage forms in order to improve the release rate of poorly water soluble drugs (i.e., HCT and CEL) via the formulation of solid dispersions. PVOH grades (DH >70%) were able to solubilize HCT and CEL up to 15%...
متن کاملHot Melt Extrusion Technique
Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...
متن کاملA Review of Hot Melt Extrusion Technique
Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems.HME is a solvent ...
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ژورنال
عنوان ژورنال: International Journal of Research in Ayurveda & Pharmacy
سال: 2016
ISSN: 2277-4343
DOI: 10.7897/2277-4343.075201